Cerebellar signatures of vestibulo-ocular reflex motor learning.

1 2 3 The bidirectionality of motor learning in the vestibulo - ocular reflex is a function of 4 cerebellar mGluR 1 receptors 5 6

Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular Reflex

Cerebellar long-term depression (LTD) is a model system for neuronal information storage that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed to underlie several forms of cerebellar motor learning. Previous studies using various knockout mice (mGluR1, GluRdelta2, glial fibrillary acidic protein) have supported this claim; however, this work has suffered...

A Recipe for Bidirectional Motor Learning: Using Inhibition to Cook Plasticity in the Vestibular Nuclei

In this issue of Neuron, McElvain et al. demonstrate for the first time plasticity at the synapse between vestibular nerve afferents and their postsynaptic targets in the medial vestibular nuclei. This new type of plasticity, which is gated by inhibition, is well suited to drive motor learning during adaptation of the vestibulo-ocular reflex.

Impaired motor learning in the vestibulo-ocular reflex in mice with multiple climbing fiber input to cerebellar Purkinje cells.

A unique feature of the cerebellar architecture is that Purkinje cells in the cerebellar cortex each receive input from a single climbing fiber. In mice deficient in the gamma isoform of protein kinase C (PKCgamma-/- mice), this normal architecture is disrupted so that individual Purkinje cells receive input from multiple climbing fibers. These mice have no other known abnormalities in the cere...

The bidirectionality of motor learning in the vestibulo-ocular reflex is a function of cerebellar mGluR1 receptors.

Bidirectional changes in synaptic transmission have the potential to optimize the control of movement. However, it can be difficult to establish a causal relationship between the bidirectionality of synaptic plasticity and bidirectional changes in the speed of actual movements. We asked whether metabotropic glutamate receptor 1 (mGluR1) receptors, which participate in cerebellar long-term depre...